2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1798):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-154578
    N1-Methyl-2'-deoxyadenosine
    N1-Methyl-2'-deoxyadenosine, DNA adduct is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N1-Methyl-2'-deoxyadenosine
  • HY-13538A
    Gemcitabine elaidate hydrochloride
    		Inhibitor 99.89%
    Gemcitabine elaidate (CP-4126) hydrochloride is lipophilic pro-agent of Gemcitabine. Gemcitabine elaidate hydrochloride is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate hydrochloride exhibits anti-tumor activity.
    Gemcitabine elaidate hydrochloride
  • HY-W587488
    Adenosine 3′-monophosphate
    		≥98.0%
    Adenosine 3′-monophosphate (3′-AMP), a nucleotide, is a cyclic AMP production agonist.
    Adenosine 3′-monophosphate
  • HY-W011683
    2'-Deoxyadenosine monohydrate
    		99.89%
    2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer.
    2'-Deoxyadenosine monohydrate
  • HY-W009538
    5'-Deoxy-5-fluorocytidine
    		99.91%
    5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer.
    5'-Deoxy-5-fluorocytidine
  • HY-128671
    6-​Thioinosine
    		98.82%
    6-​Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα.
    6-​Thioinosine
  • HY-154510
    2’-Deoxy-N4-methylcytidine
    		98.04%
    2’-Deoxy-N4-methylcytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Deoxy-N4-methylcytidine
  • HY-B1449S
    Uridine-15N2
    		98.00%
    Uridine-15N2 is the 15N labeled Uridine.
    Uridine-<sup>15</sup>N<sub>2</sub>
  • HY-148506
    5'-ODMT cEt m5U Phosphoramidite (Amidite)
    		99.25%
    5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity in mice.
    5'-ODMT cEt m5U Phosphoramidite (Amidite)
  • HY-45409
    DMT-2′Fluoro-dU Phosphoramidite
    		98.83%
    DMT-2′Fluoro-dU Phosphoramidite could be used for nucleoside modification.
    DMT-2′Fluoro-dU Phosphoramidite
  • HY-W587829
    4-Thiothymidine
    		99.67%
    4-Thiothymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    4-Thiothymidine
  • HY-W008388
    Bz-rA
    		99.51%
    Bz-rA (N6-Benzoyladenosine) is a N6-protected adenosine that can be used to synthesize oligoribonucleotides.
    Bz-rA
  • HY-13672
    LY2334737
    		Inhibitor 98.55%
    LY2334737 is an nucleoside analog and is an orally active proagent of Gemcitabine. LY2334737 exhibits inhibitory activity against enterovirus A71 (EV-A71) infection. LY2334737 has antiviral and anticancer effects.
    LY2334737
  • HY-W251687
    2'-Deoxy-2'-fluoroarabinoadenosine
    		99.92%
    2'-Deoxy-2'-fluoroarabinoadenosine is a nucleoside analogue, which exhibits anticancer activity against human immunodeficiency virus (HIV).
    2'-Deoxy-2'-fluoroarabinoadenosine
  • HY-19743
    Triazavirin
    		99.15%
    Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent. Triazavirin works by inhibiting the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is also an effective protective agent on the transmission stage of influenza.
    Triazavirin
  • HY-102018
    3'-Deoxy-3'-fluoroadenosine
    		99.29%
    3'-Deoxy-3'-fluoroadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3'-Deoxy-3'-fluoroadenosine
  • HY-138610
    5'-O-DMT-Bz-rC
    		99.69%
    5'-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.
    5'-O-DMT-Bz-rC
  • HY-125650
    Pseudouridimycin
    Pseudouridimycin (PUM) is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC50 of about 0.1 μM and MICs of 4-6 μg/mL. Pseudouridimycin is a C-nucleoside analogue that's effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis.
    Pseudouridimycin
  • HY-113225S5
    Guanosine triphosphate-13C10 dilithium
    Guanosine triphosphate-13C10 (GTP-13C10) dilithium is 13C-labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.
    Guanosine triphosphate-<sup>13</sup>C<sub>10</sub> dilithium
  • HY-21286
    N2-Isobutyryl-2'-O-methylguanosine
    		99.97%
    N2-Isobutyryl-2'-O-methylguanosine (N2-IBU-2'-OME-RG) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N2-Isobutyryl-2'-O-methylguanosine